Heat the oven to 350°F. Line the bottom and sides of an 8x8-inch square metal baking pan with 2 sheets of parchment paper.

Break 16 whole graham cracker sheets into rough pieces and place in a food processor. Add ¼ cup granulated sugar and ¼ teaspoon of the kosher salt. Process until the crackers are the texture of sand, about 15 seconds.

Add 9 tablespoons melted unsalted butter and pulse to combine, 8 to 10 pulses. Reserve ⅔ cup of the mixture for topping.

Transfer the remaining mixture to the baking pan. Use the bottom of a flat measuring cup or your fingers to press the crumbs into an even layer.

Bake until fragrant and starting to darken around the edges, 12 to 15 minutes.

Wipe the food processor clean. Place 16 ounces room-temperature cream cheese in the food processor. Process until very smooth and fluffy, 1 to 2 minutes.

Add ½ cup granulated sugar, 2 teaspoons finely grated lemon zest, 3 tablespoons lemon juice, 1 teaspoon vanilla extract, and ¼ teaspoon kosher salt. Process until combined, about 30 seconds.

With the motor running, add 2 room-temperature large eggs one at a time and process until just incorporated.

Add 1 ½ cups of the blueberries and gently stir to combine. Transfer to the graham cracker crust and spread into an even layer. Scatter the remaining ½ cup blueberries over the top.

Sprinkle with the reserved crumb mixture. Bake until edges are set and puffed, 30 to 35 minutes.

Let cool completely, about 2 hours. Cover and refrigerate until chilled, at least 3 hours or up to overnight.

Lift the slab out of the pan and place on a cutting board. Dust with powdered sugar if using. Cut into 9 or 12 bars.